| Pick | Team | Selection and Notes |
| St. Louis | Sam Bradford, QB, Oklahoma | |
| Detroit | Ndamukong Suh, DT, Nebraska | |
| Tampa Bay | Gerald McCoy, DT, Oklahoma | |
| Washington | Trent Williams, OT, Oklahoma | |
| Kansas City | Eric Berry, S, Tennessee | |
| Seattle | Russell Okung, OT, Oklahoma State | |
| Cleveland | Joe Haden, CB, Florida | |
| Oakland | Rolando McClain, MLB, Alabama | |
| Buffalo | C.J. Spiller, RB, Clemson | |
| Jacksonville | Tyson Alualu, DT, California | |
| San Francisco | Anthony Davis, OT, Rutgers From Chicago through Denver | |
| San Diego | Ryan Matthews, RB, Fresno State From Miami | |
| Philadelphia | Brandon Graham, OLB, Michigan From San Francisco through Denver | |
| Seattle | Earl Thomas, S, Texas From Denver | |
| New York Giants | Jason Pierre-Paul, DE, South Florida | |
| Tennessee | Derrick Morgan, DE, Georgia Tech | |
| San Francisco | Mike Iupati, OG, Idaho From Carolina | |
| Pittsburgh | Maurkice Pouncey, C, Florida | |
| Atlanta | Sean Witherspoon, OLB, Missouri | |
| Houston | Kareem Jackson, CB, Alabama | |
| Cincinnati | Jermaine Gresham, TE, Oklahoma | |
| Denver | Demaryius Thomas, WR, Georgia Tech From New England | |
| Green Bay | Bryan Bulaga, OT, Iowa | |
| Dallas | Dez Bryant, WR, Oklahoma State From Philadelphia through Denver and NE | |
| Denver | Tim Tebow, QB, Florida From Baltimore | |
| Arizona | Dan Williams, DT, Tennessee | |
| New England | Devin McCourty, CB, Rutgers From Dallas | |
| Miami | Jared Odrick, DT, Penn State | |
| New York Jets | Kyle Wilson, CB, Boise State | |
| Detroit | Jahvid Best, RB, California From Minnesota | |
| Indianapolis | Jerry Hughes, OLB, TCU | |
| New Orleans | Patrick Robinson, CB, Florida State |
| Pick | Team | Selection and Notes |
| St. Louis | Roger Saffold, OT, Indiana | |
| Minnesota | Chris Cook, CB, Virginia From Lions | |
| Tampa Bay | Brian Price, DT, UCLA | |
| Kansas City | Dexter McCluster, WR, Mississippi | |
| Philadelphia | Nate Allen, S, South Florida From Washington | |
| Cleveland | T.J. Ward, S, Oregon | |
| Tampa Bay | Arrelious Benn, WR, Illinois From Raiders | |
| Miami | Koa Misi, OLB, Utah From Seattle thorugh San Diego | |
| Buffalo | Torrell Troup, DT, UCF | |
| New England | Rob Gronkowski, TE, Arizona From Chicago, through TB and Oak | |
| Baltimore | Sergio Kindle, OLB, Texas From Miami through Denver | |
| Oakland | Larmarr Houston, DT, Texas From Jacksonville | |
| Denver | Zane Beadles, OT, Utah | |
| New York Giants | Linval Joseph, DT, East Carolina | |
| Cardinals | Daryl Washington, MLB, TCU From Tennessee through New England | |
| Carolina | Jimmy Clausen, QB, Notre Dame | |
| San Francisco | Taylor Mays, S, USC | |
| Kansas City | Javier Arenas, CB, Alabama From Atlanta | |
| Vikings | Toby Gerhart, RB, Stanford From Houston | |
| Pittsburgh | Jason Worilds, DE, Virginia Tech | |
| New England | Jermaine Cunningham, DE, Florida | |
| Cincinnati | Carlos Dunlap, DE, Florida | |
| Cowboys | Sean Lee, MLB, Penn State From Philadelphia | |
| Green Bay | Mike Neal, DT, Purdue | |
| Baltimore | Terrence Cody, DT, Alabama | |
| Houston | Ben Tate, RB, Auburn From Arizona through New England | |
| Cleveland | Montario Hardesty, RB, Tennessee From Dallas Through Phil | |
| Seattle | Golden Tate, WR, Notre Dame From San Diego | |
| New York Jets | Vladimir Ducasse, OG, Massachusetts | |
| New England | Brandon Spikes, MLB, Florida From Vikings through Texans | |
| Indianapolis | Pat Angerer, MLB, Iowa | |
| New Orleans | Charles Brown, OT, USC |